Introduction to Genomics for Engineers(learngenomics.dev)
248 points by yreg 4 days ago | 40 comments
tl;dr: A primer on cancer genomics aimed at computer scientists, explaining DNA as a ~3 billion character string of A/C/T/G bases organized into 23 chromosome pairs, with genes serving as "recipes" (analogized to a bakery cookbook) that cells use to produce proteins. It covers the double-stranded complementary structure of DNA, chromosome organization, and how mutations in this system can lead to cancer, setting up genotype-phenotype analysis as the basis for personalized medicine.
HN Discussion:
  • ~Guide is a good introduction but contains oversimplifications requiring further study for real-world work
  • ~Article underplays how stochastic, fuzzy, and messy biology actually is compared to its clean computational framing
  • Personal endorsement as useful learning material matching their own background/interests
  • Recommendation of deeper resources like Bioinformatics Algorithms for engineers wanting more depth
  • Context about the authoring organization (St. Jude) adding credibility and interest